New Research Links 'Forever Chemicals' to Adolescent Liver Disease
A recent study co-led by the University of Hawaiʻi at Mānoa has identified a significant link between exposure to certain per- and polyfluoroalkyl substances (PFAS), commonly known as 'forever chemicals,' and an increased risk of liver disease in adolescents. The research suggests that exposure to these synthetic compounds may as much as triple the risk of developing liver disease in this demographic. While the study focused on adolescent populations, the findings raise broader concerns about the pervasive presence of PFAS in everyday products and the environment, suggesting potential downstream health impacts and associated costs.
Who's Affected
- Small Business Operators: Businesses that utilize or sell products containing PFAS-treated materials (e.g., certain food packaging, textiles, non-stick cookware) may face increased scrutiny and potential future demand for PFAS-free alternatives. This could lead to shifts in supply chain costs and product development.
- Real Estate Owners: While not directly addressed in this study, the presence of PFAS in building materials and water systems can impact property value and necessitate costly remediation efforts. This research heightens awareness of the broader environmental health risks associated with contaminated sites.
- Agriculture & Food Producers: Producers of food and beverages are particularly vulnerable, as PFAS can migrate from packaging, processing equipment, and contaminated water or soil into food products. This could lead to increased testing requirements, product recalls, or consumer avoidance.
- Healthcare Providers: This study directly impacts healthcare providers by highlighting a potential increase in diagnostic and treatment needs for liver conditions in adolescents. Over the long term, this could translate to increased demand for specialized care, diagnostic services, and potentially higher insurance claims and public health burdens related to chronic disease management.
- Entrepreneurs & Startups: Startups developing consumer goods, food products, or health-related technologies should be acutely aware of the growing body of research on PFAS. Identifying and marketing PFAS-free alternatives presents a market opportunity, while failing to account for these risks could lead to product obsolescence or regulatory hurdles.
Second-Order Effects
- Increased public and regulatory awareness of PFAS → Pressure for stricter environmental regulations on chemical use and waste disposal → Higher compliance costs for businesses in manufacturing and agriculture → Potential for increased consumer prices on goods that require PFAS-free alternatives or enhanced safety measures.
- Growing body of research on PFAS health impacts → Increased demand for medical diagnostics and treatments for associated conditions (e.g., liver disease) → Strain on healthcare systems and potential for rising health insurance premiums for businesses.
- Consumer demand for PFAS-free products → Shift in manufacturing and retail supply chains → Opportunities for innovation and new market entrants offering 'clean' alternatives, but potential disruption for established businesses relying on PFAS-containing materials.
What to Do
Given the ongoing nature of PFAS research and the potential for future regulatory action, businesses are advised to adopt a proactive monitoring stance.
- Small Business Operators: Begin reviewing the materials and packaging used in your products and operations. Consult with suppliers about the presence of PFAS and inquire about PFAS-free alternatives. Consider the long-term implications for employee health programs if your sector is directly impacted by environmental contaminants.
- Real Estate Owners: If you manage properties with a history of industrial use, or properties reliant on well water, consider environmental site assessments for PFAS contamination. Stay informed about local and state initiatives for water quality monitoring and remediation.
- Agriculture & Food Producers: Conduct a thorough review of your packaging materials, water sources, and any processing aids for potential PFAS contamination. Engage with industry associations to understand best practices and emerging regulatory landscapes. Prioritize sourcing from suppliers who can demonstrate PFAS-free practices.
- Healthcare Providers: Incorporate awareness of potential PFAS-related health risks into adolescent health screenings. Stay updated on diagnostic guidelines for liver health in at-risk populations. Consider the long-term implications for patient management and population health initiatives.
- Entrepreneurs & Startups: If your business involves consumer products, food, or materials science, prioritize research and development of PFAS-free formulations. Highlight your commitment to safety and environmental responsibility in your product positioning and marketing.
Action Details: Monitor guidance from regulatory bodies such as the U.S. Environmental Protection Agency (EPA) and the Hawaiʻi Department of Health regarding PFAS. Watch for industry-led initiatives to phase out PFAS in consumer goods and food packaging. If widespread bans or strict limits on common PFAS are enacted, such as those beginning to emerge at the state level in the continental US, businesses should be prepared to pivot to alternative materials promptly.



